Thomas P Loughran Selected Research

Fas Ligand Protein (Fas Ligand)

2/2005	Constitutive production of proinflammatory cytokines RANTES, MIP-1beta and IL-18 characterizes LGL leukemia.
8/2002	Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia.

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Thomas P Loughran Research Topics

Disease

49	Large Granular Lymphocytic Leukemia 08/2022 - 12/2002
44	Neoplasms (Cancer) 04/2024 - 08/2003
27	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2024 - 08/2003
20	Leukemia 03/2023 - 08/2003
6	Hematologic Neoplasms (Hematological Malignancy) 01/2019 - 03/2002
5	Infections 08/2022 - 04/2003
5	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 08/2002
4	Cytopenia 10/2013 - 08/2003
3	Disease Progression 09/2021 - 08/2003
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2018 - 12/2002
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2016 - 08/2003
3	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 05/2012 - 05/2010
2	Carcinogenesis 01/2022 - 01/2012
2	Multiple Myeloma 01/2020 - 01/2010
2	Felty Syndrome (Syndrome, Felty's) 01/2018 - 09/2006
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2017 - 01/2013
2	Genetic Translocation (Chromosomal Translocation) 01/2017 - 12/2002
2	T-Cell Prolymphocytic Leukemia (Leukemia, T Cell, Chronic) 03/2016 - 06/2015
2	Breast Neoplasms (Breast Cancer) 01/2016 - 07/2011
2	Hemorrhage 03/2015 - 01/2002
2	Hepatocellular Carcinoma (Hepatoma) 01/2015 - 11/2014
2	Anemia 09/2012 - 03/2011
2	T-Cell Leukemia (Leukemia, T Cell) 05/2012 - 04/2003
2	Neutropenia 03/2011 - 02/2005
1	COVID-19 08/2022
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2022
1	Thrombocytopenia (Thrombopenia) 01/2021
1	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2019
1	Rheumatoid Arthritis 01/2018

Drug/Important Bio-Agent (IBA)

19	SphingolipidsIBA 01/2022 - 08/2008
16	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2003
15	CeramidesIBA 03/2023 - 11/2010
13	CytokinesIBA 01/2020 - 02/2003
10	AntigensIBA 01/2022 - 07/2003
6	Interleukin-15 (Interleukin 15)IBA 01/2019 - 05/2009
5	Acid CeramidaseIBA 12/2023 - 07/2015
5	N-caproylsphingosineIBA 01/2017 - 01/2013
5	Methotrexate (Mexate)FDA LinkGeneric 07/2012 - 08/2003
5	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/2012 - 08/2003
4	AntibodiesIBA 01/2024 - 01/2012
4	Tamoxifen FDA LinkGeneric 01/2019 - 07/2015
4	Calcitriol (Calcijex)FDA LinkGeneric 11/2018 - 01/2017
4	sphingosine kinaseIBA 07/2017 - 10/2008
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 05/2008 - 08/2003
3	Adenosine Triphosphate (ATP)IBA 04/2024 - 01/2013
3	Cytarabine (Cytosar-U)FDA LinkGeneric 10/2022 - 04/2016
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 05/2010
3	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2020 - 05/2012
3	N'- ((1E)- 1- (3,4- dimethoxyphenyl)ethylidene)- 3- (4- methoxyphenyl)- 1H- pyrazole- 5- carbohydrazideIBA 07/2017 - 01/2015
3	Farnesyltranstransferase (Farnesyltransferase)IBA 04/2012 - 12/2008
2	IronIBA 12/2023 - 10/2023
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022 - 10/2005
2	ChemokinesIBA 01/2022 - 02/2005
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 04/2012
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 03/2013
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 01/2017
2	Interleukin-2 (IL2)IBA 01/2019 - 04/2003
2	Tyrosine (L-Tyrosine)FDA Link 11/2018 - 01/2018
2	Proteasome InhibitorsIBA 01/2018 - 05/2009
2	Interferon-gamma (Interferon, gamma)IBA 01/2018 - 04/2003
2	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2018 - 03/2017
2	EnzymesIBA 06/2017 - 07/2015
2	CalciumIBA 03/2017 - 07/2011
2	Vitamin D FDA LinkGeneric 03/2017 - 01/2017
2	Cadherins (E-Cadherin)IBA 01/2015 - 11/2014
2	marinopyrrole AIBA 08/2014 - 03/2012
2	EpitopesIBA 05/2012 - 04/2005
2	Peptides (Polypeptides)IBA 05/2012 - 04/2005
2	Interleukin-12 (IL 12)IBA 04/2012 - 02/2005
2	tipifarnib (R115777)IBA 04/2012 - 05/2010
2	Sphingosine-1-Phosphate ReceptorsIBA 11/2011 - 12/2002
2	Fingolimod Hydrochloride (FTY720)FDA Link 09/2011 - 08/2008
2	Neutralizing AntibodiesIBA 04/2011 - 01/2010
2	GlucocorticoidsIBA 05/2008 - 09/2006
2	Amino Acids FDA Link 04/2005 - 11/2003
2	RNA (Ribonucleic Acid)IBA 02/2005 - 05/2003
2	Fas Ligand Protein (Fas Ligand)IBA 02/2005 - 08/2002
1	Aligeron (AS 2)IBA 03/2024
1	CaspasesIBA 03/2023
1	venetoclaxIBA 10/2022
1	VaccinesIBA 08/2022
1	AutoantibodiesIBA 01/2022
1	HLA-DR4 Antigen (HLA DR4 Antigen)IBA 01/2022
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2022
1	LuciferasesIBA 09/2021
1	Protein Kinases (Protein Kinase)IBA 09/2021
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021
1	IsatinIBA 01/2020
1	Aldehyde DehydrogenaseIBA 01/2020
1	Agammaglobulinaemia Tyrosine KinaseIBA 01/2020
1	Daunorubicin (Cerubidine)FDA LinkGeneric 01/2019
1	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2019
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2018
1	Bortezomib (Velcade)FDA Link 01/2018
1	Messenger RNA (mRNA)IBA 01/2018
1	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2018

Therapy/Procedure

24	Therapeutics 01/2019 - 08/2003
7	Drug Therapy (Chemotherapy) 04/2024 - 07/2003
4	Immunotherapy 08/2022 - 03/2002